Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: a pilot study.
Identifieur interne : 003208 ( Main/Exploration ); précédent : 003207; suivant : 003209Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: a pilot study.
Auteurs : Andrew Court [Australie] ; Claudia Mulder ; Melissa Kerr ; Hok Pan Yuen ; Melissa Boasman ; Sherilyn Goldstone ; Judith Fleming ; Susan Weigall ; Harry Derham ; Chia Huang ; Patrick Mcgorry ; Gregor BergerSource :
- Journal of psychiatric research [ 1879-1379 ] ; 2010.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Analyse de variance (MeSH), Anorexie mentale (physiopathologie), Anorexie mentale (rééducation et réadaptation), Anorexie mentale (traitement médicamenteux), Dibenzothiazépines (usage thérapeutique), Enquêtes et questionnaires (MeSH), Facteurs temps (MeSH), Femelle (MeSH), Fumarate de quétiapine (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Neuroleptiques (usage thérapeutique), Projets pilotes (MeSH), Protocoles cliniques (MeSH), Psychothérapie (méthodes), Résultat thérapeutique (MeSH), Échelles d'évaluation en psychiatrie (MeSH), Études de suivi (MeSH).
- MESH :
- méthodes : Psychothérapie.
- physiopathologie : Anorexie mentale.
- rééducation et réadaptation : Anorexie mentale.
- traitement médicamenteux : Anorexie mentale.
- usage thérapeutique : Dibenzothiazépines, Neuroleptiques.
- Adolescent, Adulte, Analyse de variance, Enquêtes et questionnaires, Facteurs temps, Femelle, Fumarate de quétiapine, Humains, Jeune adulte, Mâle, Projets pilotes, Protocoles cliniques, Résultat thérapeutique, Échelles d'évaluation en psychiatrie, Études de suivi.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Analysis of Variance (MeSH), Anorexia Nervosa (drug therapy), Anorexia Nervosa (physiopathology), Anorexia Nervosa (rehabilitation), Antipsychotic Agents (therapeutic use), Clinical Protocols (MeSH), Dibenzothiazepines (therapeutic use), Female (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Male (MeSH), Pilot Projects (MeSH), Psychiatric Status Rating Scales (MeSH), Psychotherapy (methods), Quetiapine Fumarate (MeSH), Surveys and Questionnaires (MeSH), Time Factors (MeSH), Treatment Outcome (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Antipsychotic Agents, Dibenzothiazepines.
- drug therapy : Anorexia Nervosa.
- methods : Psychotherapy.
- physiopathology : Anorexia Nervosa.
- rehabilitation : Anorexia Nervosa.
- Adolescent, Adult, Analysis of Variance, Clinical Protocols, Female, Follow-Up Studies, Humans, Male, Pilot Projects, Psychiatric Status Rating Scales, Quetiapine Fumarate, Surveys and Questionnaires, Time Factors, Treatment Outcome, Young Adult.
Abstract
To investigate the safety and tolerability of the atypical antipsychotic quetiapine in anorexia nervosa patients, and to determine the effect of quetiapine treatment on anorexic psychopathology and other key outcome measures including weight and body image, we conducted a naturalistic, open-label, 12-week randomized controlled trial of low-dose (100-400 mg/day) quetiapine treatment versus treatment as usual in 33 anorexia nervosa patients from our Eating Disorder Clinics. To monitor the effects of treatment over the medium term, the participants were then followed up with assessment visits at 6 and 12 months after the end of the treatment phase. Low-dose quetiapine treatment resulted in both psychological and physical improvements, with minimal associated side-effects. Given the overall trend toward improvement that we observed, quetiapine appears to be a promising candidate for the treatment of anorexia nervosa. Further large-scale placebo-controlled clinical trials will be necessary to fully evaluate the benefits of quetiapine treatment for this disorder.
DOI: 10.1016/j.jpsychires.2010.03.011
PubMed: 20447652
Affiliations:
Links toward previous steps (curation, corpus...)
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(MeSH)</term><term>Facteurs temps (MeSH)</term><term>Femelle (MeSH)</term><term>Fumarate de quétiapine (MeSH)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Neuroleptiques (usage thérapeutique)</term><term>Projets pilotes (MeSH)</term><term>Protocoles cliniques (MeSH)</term><term>Psychothérapie (méthodes)</term><term>Résultat thérapeutique (MeSH)</term><term>Échelles d'évaluation en psychiatrie (MeSH)</term><term>Études de suivi (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antipsychotic Agents</term><term>Dibenzothiazepines</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anorexia Nervosa</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychotherapy</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Psychothérapie</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Anorexie mentale</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anorexia Nervosa</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Anorexia Nervosa</term></keywords><keywords scheme="MESH" qualifier="rééducation et réadaptation" xml:lang="fr"><term>Anorexie mentale</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Anorexie mentale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Dibenzothiazépines</term><term>Neuroleptiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Analysis of Variance</term><term>Clinical Protocols</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Pilot Projects</term><term>Psychiatric Status Rating Scales</term><term>Quetiapine Fumarate</term><term>Surveys and Questionnaires</term><term>Time Factors</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Analyse de variance</term><term>Enquêtes et questionnaires</term><term>Facteurs temps</term><term>Femelle</term><term>Fumarate de quétiapine</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Projets pilotes</term><term>Protocoles cliniques</term><term>Résultat thérapeutique</term><term>Échelles d'évaluation en psychiatrie</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the safety and tolerability of the atypical antipsychotic quetiapine in anorexia nervosa patients, and to determine the effect of quetiapine treatment on anorexic psychopathology and other key outcome measures including weight and body image, we conducted a naturalistic, open-label, 12-week randomized controlled trial of low-dose (100-400 mg/day) quetiapine treatment versus treatment as usual in 33 anorexia nervosa patients from our Eating Disorder Clinics. To monitor the effects of treatment over the medium term, the participants were then followed up with assessment visits at 6 and 12 months after the end of the treatment phase. Low-dose quetiapine treatment resulted in both psychological and physical improvements, with minimal associated side-effects. Given the overall trend toward improvement that we observed, quetiapine appears to be a promising candidate for the treatment of anorexia nervosa. Further large-scale placebo-controlled clinical trials will be necessary to fully evaluate the benefits of quetiapine treatment for this disorder.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20447652</PMID><DateCompleted><Year>2011</Year><Month>02</Month><Day>10</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1379</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>15</Issue><PubDate><Year>2010</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of psychiatric research</Title><ISOAbbreviation>J Psychiatr Res</ISOAbbreviation></Journal><ArticleTitle>Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: a pilot study.</ArticleTitle><Pagination><MedlinePgn>1027-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jpsychires.2010.03.011</ELocationID><Abstract><AbstractText>To investigate the safety and tolerability of the atypical antipsychotic quetiapine in anorexia nervosa patients, and to determine the effect of quetiapine treatment on anorexic psychopathology and other key outcome measures including weight and body image, we conducted a naturalistic, open-label, 12-week randomized controlled trial of low-dose (100-400 mg/day) quetiapine treatment versus treatment as usual in 33 anorexia nervosa patients from our Eating Disorder Clinics. To monitor the effects of treatment over the medium term, the participants were then followed up with assessment visits at 6 and 12 months after the end of the treatment phase. Low-dose quetiapine treatment resulted in both psychological and physical improvements, with minimal associated side-effects. Given the overall trend toward improvement that we observed, quetiapine appears to be a promising candidate for the treatment of anorexia nervosa. Further large-scale placebo-controlled clinical trials will be necessary to fully evaluate the benefits of quetiapine treatment for this disorder.</AbstractText><CopyrightInformation>Copyright © 2010 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Court</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Orygen Youth Health, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Parkville, VIC 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulder</LastName><ForeName>Claudia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Kerr</LastName><ForeName>Melissa</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Hok Pan</ForeName><Initials>HP</Initials></Author><Author ValidYN="Y"><LastName>Boasman</LastName><ForeName>Melissa</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Goldstone</LastName><ForeName>Sherilyn</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Fleming</LastName><ForeName>Judith</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Weigall</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Derham</LastName><ForeName>Harry</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Chia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>McGorry</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>Gregor</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>05</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Psychiatr Res</MedlineTA><NlmUniqueID>0376331</NlmUniqueID><ISSNLinking>0022-3956</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014150">Antipsychotic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003987">Dibenzothiazepines</NameOfSubstance></Chemical><Chemical><RegistryNumber>2S3PL1B6UJ</RegistryNumber><NameOfSubstance UI="D000069348">Quetiapine Fumarate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000856" MajorTopicYN="N">Anorexia Nervosa</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000534" MajorTopicYN="N">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014150" MajorTopicYN="N">Antipsychotic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002985" MajorTopicYN="N">Clinical Protocols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003987" MajorTopicYN="N">Dibenzothiazepines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011569" MajorTopicYN="N">Psychiatric Status Rating Scales</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011613" MajorTopicYN="N">Psychotherapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000069348" MajorTopicYN="N">Quetiapine Fumarate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>10</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>03</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>03</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20447652</ArticleId><ArticleId IdType="pii">S0022-3956(10)00086-5</ArticleId><ArticleId IdType="doi">10.1016/j.jpsychires.2010.03.011</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Berger, Gregor" sort="Berger, Gregor" uniqKey="Berger G" first="Gregor" last="Berger">Gregor Berger</name><name sortKey="Boasman, Melissa" sort="Boasman, Melissa" uniqKey="Boasman M" first="Melissa" last="Boasman">Melissa Boasman</name><name sortKey="Derham, Harry" sort="Derham, Harry" uniqKey="Derham H" first="Harry" last="Derham">Harry Derham</name><name sortKey="Fleming, Judith" sort="Fleming, Judith" uniqKey="Fleming J" first="Judith" last="Fleming">Judith Fleming</name><name sortKey="Goldstone, Sherilyn" sort="Goldstone, Sherilyn" uniqKey="Goldstone S" first="Sherilyn" last="Goldstone">Sherilyn Goldstone</name><name sortKey="Huang, Chia" sort="Huang, Chia" uniqKey="Huang C" first="Chia" last="Huang">Chia Huang</name><name sortKey="Kerr, Melissa" sort="Kerr, Melissa" uniqKey="Kerr M" first="Melissa" last="Kerr">Melissa Kerr</name><name sortKey="Mcgorry, Patrick" sort="Mcgorry, Patrick" uniqKey="Mcgorry P" first="Patrick" last="Mcgorry">Patrick Mcgorry</name><name sortKey="Mulder, Claudia" sort="Mulder, Claudia" uniqKey="Mulder C" first="Claudia" last="Mulder">Claudia Mulder</name><name sortKey="Weigall, Susan" sort="Weigall, Susan" uniqKey="Weigall S" first="Susan" last="Weigall">Susan Weigall</name><name sortKey="Yuen, Hok Pan" sort="Yuen, Hok Pan" uniqKey="Yuen H" first="Hok Pan" last="Yuen">Hok Pan Yuen</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Court, Andrew" sort="Court, Andrew" uniqKey="Court A" first="Andrew" last="Court">Andrew Court</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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